The University of Kansas Center for Research on Learning (KUCRL) is a multidisciplinary research team whose overarching goal is Creating Solutions to Educational Challenges. KUCRL is dedicated to development and research of educational programs and practices that improve outcomes for all learners, including those with learning differences or disabilities. Our recent research and development focuses on online learning for students with disabilities, personalized learning in blended learning classrooms, and the use of technology (e.g., social media, games, virtual reality) to enhance learning for all students. KUCRL is home to the Strategic Instruction Model (SIM), an evidenced based collection of learning strategies, content enhancement teaching routines, and explicit instruction programs. These interventions and practices address higher-order reasoning skills, adolescent literacy, adult literacy, language and reading comprehension strategies, written expression strategies, math skills and strategies, social emotional learning skills, and explicit instruction and routines that respond to diversity in today’s schools.